Of Men and Angels is an Optional Honor Story Mission in Red Dead Redemption 2. This Walkthrough shows how to complete this Mission. Playing it is required for the missable 
Lending a Hand trophy.
Quest Giver: Sister Calderón
Region: Saint Denis
Requirements: having played Brothers and Sisters, One and All in Chapter 4
Availability: between A Fork in the Road and The Fine Art of Conversation
Reward: Honor
Of Men and Angels Starting Location
Starting early Chapter 6, we can meet Sister Calderón in Saint Denis, collecting donations for the poor. This only happens, if you have played Brothers and Sisters, One and All in Chapter 4. It has to be played prior to Trelawnys mission The Fine Art of Conversation or it will become unavailable after that point.
After the short but engaging conversation with her, she hopes we can give some donations for the good cause as well.
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The second part of the mission immediately starts and can also be finished on the spot. Donate either $ 10 or four items of food (or any combination like 2 items and $ 5).
To me, giving money always glitched the game and it stuck in the cinematic view; so I had to go with food, personally.
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This concludes the “Of Men and Angels” Story Missions in Red Dead Redemption 2 (RDR2). For all other Story Missions check out the full Red Dead Redemption 2 Missions Walkthrough.
I talked to the nun and donated the money ($10) but when I saved the game only “Of Men and Angels – I” was the save file rather than II. Is this going to be a problem?
Wow, me too!! Anyone with an answer before I continue with the Fine Arts Of Conversation?
You’re save game only shows part 1, if you had checked your task menu you would have seen a gold – of men and angels part 2
Damn, this quest has never been available for me. The Brothers and Sisters mission is completed in my story log and I have been checking the map for the white interrogation mark after every mission I complete. The only mission available now is the fine art of conversation and in theory I won’t be able to complete this one anymore 🙁